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R2920-2 - RSPO3 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 31 I 40 kDa Uniprot ID: Q9BXY4 Background: R-spondin-3 (RSPO3) belongs to the R-spondin family and is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Other Names: R-spondin-3, Protein with TSP type-1 repeat, Hpwtsr, Roof plate-specific spondin-3, hRspo3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human RSPO3. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extractsfrom A) mouse brain, B) human Jurkat; using anti-RSPO3 (C) (R2920-2) at RT for 2 h. |