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Quantity: 100 ul                                                                                             Application: WB

Predicted | Observed M.W.: 39 I 46 kDa                                                     Uniprot ID: Q8N6T7

Background:

NAD-dependent protein deacetylase sirtuin-6 (SIRT6) belongs to the sirtuin family and the class IV subfamily. SIRT6 is a NAD-dependent protein deacetylase and has deacetylase activity towards histone H3K9Ac and H3K56Ac. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. SIRT6 deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes.

Other Names:

NAD-dependent protein deacetylase sirtuin-6, SIR2L6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human SIRT6. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: