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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 99 kDa                                                            Uniprot ID: Q9UER7

Background:

DAXX is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. DAXX interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, DAXX functions as a potent transcription repressor that binds to sumoylated transcription factors. DAXX’s repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. DAXX also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis.

Other Names:

Death domain-associated protein 6, ETS1-associated protein 1, Fas death domain-associated protein, BING2, DAP6

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human DAXX. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: