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Quantity: 100 ul                                                                                Application: WB, IP, ChIP

Predicted I Observed M.W.: 92 kDa                                                  Uniprot ID: Q8NB78

Background:

Lysine-specific histone demethylase 1B  (KDM1B) belongs to the flavin monoamine oxidase family. KDM1B is a histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is required for de novo DNA methylation of a subset of imprinted genes during oogenesis. KDM1B demethylates both mono- and di-methylated 'Lys-4' of histone H3, but has no effect on tri-methylated 'Lys-4' or other methylated Lys residues of histone H3 or H4.

Other Names:

Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1
Lysine-specific histone demethylase 2, AOF1, C6orf193, LSD2

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human KDM1B. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

IP & ChIP: 1:100-1:200

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: