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Quantity: 100 ml                                                                                Application: WB

Predicted M.W.: 86 kDa                                                                    Uniprot ID: Q01826

Background:

Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin organizer and transcription factor that integrates chromatin architecture with gene regulation. SATB1 binds to nuclear matrix/scaffold-associating AT-rich DNA sequences (MARs/SARs). It has been shown that SATB1 interacts with promyelocytic leukemia protein (PML), and that SATB1 and PML function as a regulatory complex that controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 is implicated as a key regulator of the differentiation and activation of T cells. In cancer, SATB1 has been shown to reprogram chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Other Names:

OTTHUMP00000207689, Special AT-rich sequence-binding protein 1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human SATB1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 12 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:5,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: